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1 Cite Share Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations. Nishijima S, Stankevic E, Aasmets O, Schmidt TSB, Nagata N, Keller MI, Ferretti P, Juel HB, Fullam A, Robbani SM, Schudoma C, Hansen JK, Holm LA, Israelsen M, Schierwagen R, Torp N, Telzerow A, Hercog R, Kandels S, Hazenbrink DHM, Arumugam M, Bendtsen F, Brøns C, Fonvig CE, Holm JC, Nielsen T, Pedersen JS, Thiele MS, Trebicka J, Org E, Krag A, Hansen T, Kuhn M, Bork P; GALAXY and MicrobLiver Consortia. Nishijima S, et al. Cell. 2024 Nov 4:S0092-8674(24)01204-2. doi: 10.1016/j.cell.2024.10.022. Online ahead of print. Cell. 2024. PMID: 39541968 Cite Share Item in Clipboard
2 Cite Share Tirzepatide for Obesity Treatment and Diabetes Prevention. Jastreboff AM, le Roux CW, Stefanski A, Aronne LJ, Halpern B, Wharton S, Wilding JPH, Perreault L, Zhang S, Battula R, Bunck MC, Ahmad NN, Jouravskaya I; SURMOUNT-1 Investigators. Jastreboff AM, et al. N Engl J Med. 2024 Nov 13. doi: 10.1056/NEJMoa2410819. Online ahead of print. N Engl J Med. 2024. PMID: 39536238 Cite Share Item in Clipboard
3 Cite Share Spatiotemporal modeling of molecular holograms. Qiu X, Zhu DY, Lu Y, Yao J, Jing Z, Min KH, Cheng M, Pan H, Zuo L, King S, Fang Q, Zheng H, Wang M, Wang S, Zhang Q, Yu S, Liao S, Liu C, Wu X, Lai Y, Hao S, Zhang Z, Wu L, Zhang Y, Li M, Tu Z, Lin J, Yang Z, Li Y, Gu Y, Ellison D, Chen A, Liu L, Weissman JS, Ma J, Xu X, Liu S, Bai Y. Qiu X, et al. Cell. 2024 Nov 11:S0092-8674(24)01159-0. doi: 10.1016/j.cell.2024.10.011. Online ahead of print. Cell. 2024. PMID: 39532097 Cite Share Item in Clipboard
4 Cite Share NK2R control of energy expenditure and feeding to treat metabolic diseases. Sass F, Ma T, Ekberg JH, Kirigiti M, Ureña MG, Dollet L, Brown JM, Basse AL, Yacawych WT, Burm HB, Andersen MK, Nielsen TS, Tomlinson AJ, Dmytiyeva O, Christensen DP, Bader L, Vo CT, Wang Y, Rausch DM, Kristensen CK, Gestal-Mato M, In Het Panhuis W, Sjøberg KA, Kernodle S, Petersen JE, Pavlovskyi A, Sandhu M, Moltke I, Jørgensen ME, Albrechtsen A, Grarup N, Babu MM, Rensen PCN, Kooijman S, Seeley RJ, Worthmann A, Heeren J, Pers TH, Hansen T, Gustafsson MBF, Tang-Christensen M, Kilpeläinen TO, Myers MG Jr, Kievit P, Schwartz TW, Hansen JB, Gerhart-Hines Z. Sass F, et al. Nature. 2024 Nov 13. doi: 10.1038/s41586-024-08207-0. Online ahead of print. Nature. 2024. PMID: 39537932 Cite Share Item in Clipboard
5 Cite Share Mexico Summit 20 years on-gains and challenges. Pang T, Panisset U, Becerra-Posada F, Frenk J. Pang T, et al. Lancet. 2024 Nov 16;404(10466):1903-1905. doi: 10.1016/S0140-6736(24)02354-7. Epub 2024 Nov 10. Lancet. 2024. PMID: 39536771 No abstract available. Cite Share Item in Clipboard
6 Cite Share Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial. Guo J, Chen X, Wu M, Wang D, Zhao Y, Li Q, Tang G, Che F, Xia Z, Liang Z, Shi L, Jiang Q, Chen Y, Liu X, Ren X, Ouyang M, Wang B, You S, Billot L, Wang X, Liu Z, Jing H, Meng W, Tian S, Liu E, Xiang Y, Tang X, Xie T, Cui W, Zheng Y, Cao J, Zhang J, Wen Z, Huang T, Wang L, You C, Pan S, Cai Y, Lu Y, Hankey GJ, Al-Shahi Salman R, Anderson CS, Song L; CHAIN investigators. Guo J, et al. Lancet. 2024 Nov 12:S0140-6736(24)02261-X. doi: 10.1016/S0140-6736(24)02261-X. Online ahead of print. Lancet. 2024. PMID: 39547249 Cite Share Item in Clipboard
7 Cite Share Clinical functional proteomics of intercellular signalling in pancreatic cancer. Huang P, Gao W, Fu C, Wang M, Li Y, Chu B, He A, Li Y, Deng X, Zhang Y, Kong Q, Yuan J, Wang H, Shi Y, Gao D, Qin R, Hunter T, Tian R. Huang P, et al. Nature. 2024 Nov 13. doi: 10.1038/s41586-024-08225-y. Online ahead of print. Nature. 2024. PMID: 39537929 Cite Share Item in Clipboard
8 Cite Share A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, Raun SH, Zhao M, Coassolo L, Islam H, Oliveira B, Dai Y, Spaas J, Delgado-Gonzalez A, Donoso K, Alvarez-Buylla A, Franco-Montalban F, Letian A, Ward CP, Liu L, Svensson KJ, Goldberg EL, Gardner CD, Little JP, Banik SM, Xu Y, Long JZ. Moya-Garzon MD, et al. Cell. 2024 Nov 7:S0092-8674(24)01214-5. doi: 10.1016/j.cell.2024.10.032. Online ahead of print. Cell. 2024. PMID: 39536746 Cite Share Item in Clipboard
9 Cite Share A glutamine metabolic switch supports erythropoiesis. Lyu J, Gu Z, Zhang Y, Vu HS, Lechauve C, Cai F, Cao H, Keith J, Brancaleoni V, Granata F, Motta I, Cappellini MD, Huang LJ, DeBerardinis RJ, Weiss MJ, Ni M, Xu J. Lyu J, et al. Science. 2024 Nov 15;386(6723):eadh9215. doi: 10.1126/science.adh9215. Epub 2024 Nov 15. Science. 2024. PMID: 39541460 Cite Share Item in Clipboard
10 Cite Share Sequence modeling and design from molecular to genome scale with Evo. Nguyen E, Poli M, Durrant MG, Kang B, Katrekar D, Li DB, Bartie LJ, Thomas AW, King SH, Brixi G, Sullivan J, Ng MY, Lewis A, Lou A, Ermon S, Baccus SA, Hernandez-Boussard T, Ré C, Hsu PD, Hie BL. Nguyen E, et al. Science. 2024 Nov 15;386(6723):eado9336. doi: 10.1126/science.ado9336. Epub 2024 Nov 15. Science. 2024. PMID: 39541441 Cite Share Item in Clipboard
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Study reveals a cell-eat-cell world.
From normal vertebrate development to tumor cell cannibalism, cell-in-cell events occur in many different contexts across the tree of life
Researchers Bioengin-Ear Tissue Scaffolds to Human Scale
A new approach to sculpting human-like ears merges 3D printing, xenografts, and tissue engineering.
Do cats experience grief? New research suggests they might
Researchers from Oakland University surveyed hundreds of cat caregivers and found that cats exhibited behaviors associated with grief after a fellow cat or dog in the household died.
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Discovery of culprit behind scars in heart failure points to possible treatment target.
More than 6 million adults in the U.S. have heart failure, a condition that develops when the heart can’t pump enough blood to meet the demands of the body. While lifestyle changes and treatment can slow heart failure, there’s no cure. One reason is that heart failure and other heart conditions including heart attacks lead heart muscle to become thickened and scarred in a process known as fibrosis. Effective strategies to reverse or stop fibrosis in the heart or other organs after injury, as is needed for recovery, have remained elusive. Now, a new NIH-supported study offers a step forward in better understanding what happens in human heart failure. These findings, reported in Nature, identify a cell type that may be a main culprit in the formation of scar tissue after heart injury. What’s even more encouraging is that the study, which included mouse models, suggests that existing treatments that block communication between the immune system and the scar-forming cells may hold promise for limiting fibrosis to improve heart function.
RefSeq Release 227 is Available!
Check out RefSeq release 227, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 227 is Available! →
DiscoverWHR: Centralizing NIH’s Investments in Women’s Health Research
With DiscoverWHR—a new resource from the NIH Office of Research on Women’s Health (ORWH) and NLM—users now have easy access to NIH-funded research on the important topic of women’s health research. Explore studies, grants, clinical trials, and more on topics like menopause, PCOS, and autoimmune diseases.