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Citing Sources: What are citations and why should I use them?

What is a citation.

Citations are a way of giving credit when certain material in your work came from another source. It also gives your readers the information necessary to find that source again-- it provides an important roadmap to your research process. Whenever you use sources such as books, journals or websites in your research, you must give credit to the original author by citing the source. 

Why do researchers cite?

Scholarship is a conversation  and scholars use citations not only to  give credit  to original creators and thinkers, but also to  add strength and authority  to their own work.  By citing their sources, scholars are  placing their work in a specific context  to show where they “fit” within the larger conversation.  Citations are also a great way to  leave a trail  intended to help others who may want to explore the conversation or use the sources in their own work.

In short, citations

(1) give credit

(2) add strength and authority to your work

(3) place your work in a specific context

(4) leave a trail for other scholars

"Good citations should reveal your sources, not conceal them. They should honeslty reflect the research you conducted." (Lipson 4)

Lipson, Charles. "Why Cite?"  Cite Right: A Quick Guide to Citation Styles--MLA, APA, Chicago, the Sciences, Professions, and More . Chicago: U of Chicago, 2006. Print.

What does a citation look like?

Different subject disciplines call for citation information to be written in very specific order, capitalization, and punctuation. There are therefore many different style formats. Three popular citation formats are MLA Style (for humanities articles) and APA or Chicago (for social sciences articles).

MLA style (print journal article):  

Whisenant, Warren A. "How Women Have Fared as Interscholastic Athletic Administrators Since the Passage of Title IX." Sex Roles Vol. 49.3 (2003): 179-182.

APA style (print journal article):

Whisenant, W. A. (2003) How Women Have Fared as Interscholastic Athletic Administrators Since the Passage of Title IX. Sex Roles , 49 (3), 179-182.

Chicago style (print journal article):

Whisenant, Warren A. "How Women Have Fared as Interscholastic Athletic Administrators Since the Passage of Title IX." Sex Roles 49, no. 3 (2003): 179-182.

No matter which style you use, all citations require the same basic information:

• Author or Creator
• Container (e.g., Journal or magazine, website, edited book)
• Date of creation or publication
• Publisher 

You are most likely to have easy access to all of your citation information when you find it in the first place. Take note of this information up front, and it will be much easier to cite it effectively later.

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Home / Guides / Citation Guides / How to Cite Sources

How to Cite Sources

Here is a complete list for how to cite sources. Most of these guides present citation guidance and examples in MLA, APA, and Chicago.

If you’re looking for general information on MLA or APA citations , the EasyBib Writing Center was designed for you! It has articles on what’s needed in an MLA in-text citation , how to format an APA paper, what an MLA annotated bibliography is, making an MLA works cited page, and much more!

MLA Format Citation Examples

The Modern Language Association created the MLA Style, currently in its 9th edition, to provide researchers with guidelines for writing and documenting scholarly borrowings.  Most often used in the humanities, MLA style (or MLA format ) has been adopted and used by numerous other disciplines, in multiple parts of the world.

MLA provides standard rules to follow so that most research papers are formatted in a similar manner. This makes it easier for readers to comprehend the information. The MLA in-text citation guidelines, MLA works cited standards, and MLA annotated bibliography instructions provide scholars with the information they need to properly cite sources in their research papers, articles, and assignments.

• Book Chapter
• Conference Paper
• Documentary
• Encyclopedia
• Google Images
• Kindle Book
• Memorial Inscription
• Museum Exhibit
• Painting or Artwork
• PowerPoint Presentation
• Sheet Music
• Thesis or Dissertation
• YouTube Video

APA Format Citation Examples

The American Psychological Association created the APA citation style in 1929 as a way to help psychologists, anthropologists, and even business managers establish one common way to cite sources and present content.

APA is used when citing sources for academic articles such as journals, and is intended to help readers better comprehend content, and to avoid language bias wherever possible. The APA style (or APA format ) is now in its 7th edition, and provides citation style guides for virtually any type of resource.

Chicago Style Citation Examples

The Chicago/Turabian style of citing sources is generally used when citing sources for humanities papers, and is best known for its requirement that writers place bibliographic citations at the bottom of a page (in Chicago-format footnotes ) or at the end of a paper (endnotes).

The Turabian and Chicago citation styles are almost identical, but the Turabian style is geared towards student published papers such as theses and dissertations, while the Chicago style provides guidelines for all types of publications. This is why you’ll commonly see Chicago style and Turabian style presented together. The Chicago Manual of Style is currently in its 17th edition, and Turabian’s A Manual for Writers of Research Papers, Theses, and Dissertations is in its 8th edition.

Citing Specific Sources or Events

• Declaration of Independence
• Gettysburg Address
• Martin Luther King Jr. Speech
• President Obama’s Farewell Address
• President Trump’s Inauguration Speech
• White House Press Briefing

Additional FAQs

• Citing Archived Contributors
• Citing a Blog
• Citing a Book Chapter
• Citing a Source in a Foreign Language
• Citing an Image
• Citing a Song
• Citing Special Contributors
• Citing a Translated Article
• Citing a Tweet

6 Interesting Citation Facts

The world of citations may seem cut and dry, but there’s more to them than just specific capitalization rules, MLA in-text citations , and other formatting specifications. Citations have been helping researches document their sources for hundreds of years, and are a great way to learn more about a particular subject area.

Ever wonder what sets all the different styles apart, or how they came to be in the first place? Read on for some interesting facts about citations!

1. There are Over 7,000 Different Citation Styles

You may be familiar with MLA and APA citation styles, but there are actually thousands of citation styles used for all different academic disciplines all across the world. Deciding which one to use can be difficult, so be sure to ask you instructor which one you should be using for your next paper.

2. Some Citation Styles are Named After People

While a majority of citation styles are named for the specific organizations that publish them (i.e. APA is published by the American Psychological Association, and MLA format is named for the Modern Language Association), some are actually named after individuals. The most well-known example of this is perhaps Turabian style, named for Kate L. Turabian, an American educator and writer. She developed this style as a condensed version of the Chicago Manual of Style in order to present a more concise set of rules to students.

3. There are Some Really Specific and Uniquely Named Citation Styles

How specific can citation styles get? The answer is very. For example, the “Flavour and Fragrance Journal” style is based on a bimonthly, peer-reviewed scientific journal published since 1985 by John Wiley & Sons. It publishes original research articles, reviews and special reports on all aspects of flavor and fragrance. Another example is “Nordic Pulp and Paper Research,” a style used by an international scientific magazine covering science and technology for the areas of wood or bio-mass constituents.

4. More citations were created on  EasyBib.com  in the first quarter of 2018 than there are people in California.

The US Census Bureau estimates that approximately 39.5 million people live in the state of California. Meanwhile, about 43 million citations were made on EasyBib from January to March of 2018. That’s a lot of citations.

5. “Citations” is a Word With a Long History

The word “citations” can be traced back literally thousands of years to the Latin word “citare” meaning “to summon, urge, call; put in sudden motion, call forward; rouse, excite.” The word then took on its more modern meaning and relevance to writing papers in the 1600s, where it became known as the “act of citing or quoting a passage from a book, etc.”

6. Citation Styles are Always Changing

The concept of citations always stays the same. It is a means of preventing plagiarism and demonstrating where you relied on outside sources. The specific style rules, however, can and do change regularly. For example, in 2018 alone, 46 new citation styles were introduced , and 106 updates were made to exiting styles. At EasyBib, we are always on the lookout for ways to improve our styles and opportunities to add new ones to our list.

Why Citations Matter

Here are the ways accurate citations can help your students achieve academic success, and how you can answer the dreaded question, “why should I cite my sources?”

They Give Credit to the Right People

Citing their sources makes sure that the reader can differentiate the student’s original thoughts from those of other researchers. Not only does this make sure that the sources they use receive proper credit for their work, it ensures that the student receives deserved recognition for their unique contributions to the topic. Whether the student is citing in MLA format , APA format , or any other style, citations serve as a natural way to place a student’s work in the broader context of the subject area, and serve as an easy way to gauge their commitment to the project.

They Provide Hard Evidence of Ideas

Having many citations from a wide variety of sources related to their idea means that the student is working on a well-researched and respected subject. Citing sources that back up their claim creates room for fact-checking and further research . And, if they can cite a few sources that have the converse opinion or idea, and then demonstrate to the reader why they believe that that viewpoint is wrong by again citing credible sources, the student is well on their way to winning over the reader and cementing their point of view.

They Promote Originality and Prevent Plagiarism

The point of research projects is not to regurgitate information that can already be found elsewhere. We have Google for that! What the student’s project should aim to do is promote an original idea or a spin on an existing idea, and use reliable sources to promote that idea. Copying or directly referencing a source without proper citation can lead to not only a poor grade, but accusations of academic dishonesty. By citing their sources regularly and accurately, students can easily avoid the trap of plagiarism , and promote further research on their topic.

They Create Better Researchers

By researching sources to back up and promote their ideas, students are becoming better researchers without even knowing it! Each time a new source is read or researched, the student is becoming more engaged with the project and is developing a deeper understanding of the subject area. Proper citations demonstrate a breadth of the student’s reading and dedication to the project itself. By creating citations, students are compelled to make connections between their sources and discern research patterns. Each time they complete this process, they are helping themselves become better researchers and writers overall.

When is the Right Time to Start Making Citations?

Make in-text/parenthetical citations as you need them.

As you are writing your paper, be sure to include references within the text that correspond with references in a works cited or bibliography. These are usually called in-text citations or parenthetical citations in MLA and APA formats. The most effective time to complete these is directly after you have made your reference to another source. For instance, after writing the line from Charles Dickens’ A Tale of Two Cities : “It was the best of times, it was the worst of times…,” you would include a citation like this (depending on your chosen citation style):

(Dickens 11).

This signals to the reader that you have referenced an outside source. What’s great about this system is that the in-text citations serve as a natural list for all of the citations you have made in your paper, which will make completing the works cited page a whole lot easier. After you are done writing, all that will be left for you to do is scan your paper for these references, and then build a works cited page that includes a citation for each one.

Need help creating an MLA works cited page ? Try the MLA format generator on EasyBib.com! We also have a guide on how to format an APA reference page .

2. Understand the General Formatting Rules of Your Citation Style Before You Start Writing

While reading up on paper formatting may not sound exciting, being aware of how your paper should look early on in the paper writing process is super important. Citation styles can dictate more than just the appearance of the citations themselves, but rather can impact the layout of your paper as a whole, with specific guidelines concerning margin width, title treatment, and even font size and spacing. Knowing how to organize your paper before you start writing will ensure that you do not receive a low grade for something as trivial as forgetting a hanging indent.

Don’t know where to start? Here’s a formatting guide on APA format .

3. Double-check All of Your Outside Sources for Relevance and Trustworthiness First

Collecting outside sources that support your research and specific topic is a critical step in writing an effective paper. But before you run to the library and grab the first 20 books you can lay your hands on, keep in mind that selecting a source to include in your paper should not be taken lightly. Before you proceed with using it to backup your ideas, run a quick Internet search for it and see if other scholars in your field have written about it as well. Check to see if there are book reviews about it or peer accolades. If you spot something that seems off to you, you may want to consider leaving it out of your work. Doing this before your start making citations can save you a ton of time in the long run.

Finished with your paper? It may be time to run it through a grammar and plagiarism checker , like the one offered by EasyBib Plus. If you’re just looking to brush up on the basics, our grammar guides  are ready anytime you are.

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Citation Basics

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• Research Process
• Find Background Info
• Find Sources through the Library
• Evaluate Your Info
• Cite Your Sources
• Evaluate, Write & Cite

• is the right thing to do  to give credit to those who had the idea
• shows that you have read and understand  what experts have had to say about your topic
• helps people find the sources  that you used in case they want to read more about the topic
• provides   evidence  for your arguments
• is professional and  standard practice   for students and scholars

What is a Citation?

A citation identifies for the reader the original source for an idea, information, or image that is referred to in a work.

• In the body of a paper, the  in-text citation  acknowledges the source of information used.
• At the end of a paper, the citations are compiled on a  References  or  Works Cited  list. A basic citation includes the author, title, and publication information of the source. 

From:  Lemieux  Library,  University  of Seattle 

Why Should You Cite?

Quoting Are you quoting two or more consecutive words from a source? Then the original source should be cited and the words or phrase placed in quotes. 

Paraphrasing If an idea or information comes from another source,  even if you put it in your own words , you still need to credit the source.  General vs. Unfamiliar Knowledge You do not need to cite material which is accepted common knowledge. If in doubt whether your information is common knowledge or not, cite it. Formats We usually think of books and articles. However, if you use material from web sites, films, music, graphs, tables, etc. you'll also need to cite these as well.

Plagiarism is presenting the words or ideas of someone else as your own without proper acknowledgment of the source. When you work on a research paper and use supporting material from works by others, it's okay to quote people and use their ideas, but you do need to correctly credit them. Even when you summarize or paraphrase information found in books, articles, or Web pages, you must acknowledge the original author.

Citation Style Help

Helpful links:

• MLA ,  Works Cited : A Quick Guide (a template of core elements)
• CSE  (Council of Science Editors)

For additional writing resources specific to styles listed here visit the  Purdue OWL Writing Lab

Citation and Bibliography Resources

• How to Write an Annotated Bibliography
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Land Acknowledgement

The land on which we gather is the unceded territory of the Awaswas-speaking Uypi Tribe. The Amah Mutsun Tribal Band, comprised of the descendants of indigenous people taken to missions Santa Cruz and San Juan Bautista during Spanish colonization of the Central Coast, is today working hard to restore traditional stewardship practices on these lands and heal from historical trauma.

The land acknowledgement used at UC Santa Cruz was developed in partnership with the Amah Mutsun Tribal Band Chairman and the Amah Mutsun Relearning Program at the UCSC Arboretum .

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Citation Machine® Guides & Resources

Mla format: everything you need to know and more.

Filled with a wide variety of examples and visuals, our Citation Machine® MLA guide will help you master the citation process. Learn how to cite websites, books, journal articles, magazines, newspapers, films, social media, and more!

MLA Citation Generator | Website | Books | Journal Articles | YouTube | Images | Movies | Interview | PDFs

Comprehensive Guide to APA Format

Our Citation Machine® APA guide is a one-stop shop for learning how to cite in APA format. Read up on what APA is, or use our citing tools and APA examples to create citations for websites, books, journals, and more!

APA Citation Generator | Website | Books | Journal Articles | YouTube | Images | Movies | Interview | PDFs

Everything You Need to Know About Chicago Style

Creating citations in Chicago style has never been easier thanks to our extensive Citation Machine® Chicago style guide and tools. Learn about footnotes, endnotes, and everything in between, or easily create citations for websites, books, journal articles, and more!

Chicago Citation Generator | Website | Books | Journal Articles | YouTube | Images | Movies | Interview | PDFs

Citation Machine®’s Ultimate Writing Guides

Whether you’re a student, writer, foreign language learner, or simply looking to brush up on your grammar skills, our comprehensive grammar guides provide an extensive overview on over 50 grammar-related topics. Confused about reflexive verbs, demonstrative adjectives, or conjunctive adverbs? Look no further! Learn about these grammar topics and many, many more in our thorough and easy to understand reference guides!

Citing Sources Guide | Grammar Guide | Plagiarism Guide | Writing Tips

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Free APA Citation Generator

Generate citations in APA format quickly and automatically, with MyBib!

🤔 What is an APA Citation Generator?

An APA citation generator is a software tool that will automatically format academic citations in the American Psychological Association (APA) style.

It will usually request vital details about a source -- like the authors, title, and publish date -- and will output these details with the correct punctuation and layout required by the official APA style guide.

Formatted citations created by a generator can be copied into the bibliography of an academic paper as a way to give credit to the sources referenced in the main body of the paper.

👩‍🎓 Who uses an APA Citation Generator?

College-level and post-graduate students are most likely to use an APA citation generator, because APA style is the most favored style at these learning levels. Before college, in middle and high school, MLA style is more likely to be used. In other parts of the world styles such as Harvard (UK and Australia) and DIN 1505 (Europe) are used more often.

🙌 Why should I use a Citation Generator?

Like almost every other citation style, APA style can be cryptic and hard to understand when formatting citations. Citations can take an unreasonable amount of time to format manually, and it is easy to accidentally include errors. By using a citation generator to do this work you will:

• Save a considerable amount of time
• Ensure that your citations are consistent and formatted correctly
• Be rewarded with a higher grade

In academia, bibliographies are graded on their accuracy against the official APA rulebook, so it is important for students to ensure their citations are formatted correctly. Special attention should also be given to ensure the entire document (including main body) is structured according to the APA guidelines. Our complete APA format guide has everything you need know to make sure you get it right (including examples and diagrams).

⚙️ How do I use MyBib's APA Citation Generator?

Our APA generator was built with a focus on simplicity and speed. To generate a formatted reference list or bibliography just follow these steps:

• Start by searching for the source you want to cite in the search box at the top of the page.
• MyBib will automatically locate all the required information. If any is missing you can add it yourself.
• Your citation will be generated correctly with the information provided and added to your bibliography.
• Repeat for each citation, then download the formatted list and append it to the end of your paper.

MyBib supports the following for APA style:

Daniel is a qualified librarian, former teacher, and citation expert. He has been contributing to MyBib since 2018.

Research Basics: 5. Citing Your Sources

• 1. Selecting and Narrowing Your Topic
• 2. Effective Searching
• 3. Finding Books/eBooks/Articles
• 4. Evaluating Information
• 5. Citing Your Sources
• 6. Writing Help

The proper citation of sources is how scholars acknowledge the work of earlier scholars. Ideally, citation provides a method for tracking down the research of others by providing information about the original source so it can be easily found. Citations typically include things like article titles, journal titles, authors, dates, and publication information. 

The purpose is to make the original source of any information you reference easily findable by others and also to give credit when you use the original ideas of others. This is our responsibility as researchers. Citation also allows you to avoid plagiarism. Most every educational institution has some sort of academic integrity policy that outlines a student’s responsibilities as a researcher. 

The three most common citation styles at Polk State College are MLA, APA, and Chicago.  If you are unsure of which citation style to use, consult your professor.

What is MLA?

MLA style is a commonly used style found in the humanities including language and literature. MLA is an acronym for Modern Language Association.

MLA Style Online Guides

• MLA Overview from Excelsior OWL
• MLA Formatting and Style Guide (Purdue University OWL) Be sure to check out the sample paper and Works Cited page!
• MLA Style Center (official)
• MLA Style Citation Guide (Long Island University)
• MLA Handbook Excerpt (PDF)

MLA Style Guide Book

What is APA?

APA style is often used for writing in the fields of psychology, business, communications, nursing, history and social sciences. APA stands for the American Psychological Association.

APA Style Online Guides

• Basics of 7th Edition APA Style tutorial (official)
• APA Style and Grammar Guidelines-7th edition (official)
• APA Style (Excelsior Online Writing Lab)
• APA Formatting and Style Guide-7th edition (Purdue University OWL)

APA Style Guide Book

What is Chicago?

Chicago style citations are unique in that it includes two documentation systems. The first is known as the humanities (notes and bibliography) style and is more often used in the fields of arts and humanities. The second is the author-date system, used more often in the natural sciences.

Chicago Style Online Guides

• The Chicago Manual of Style Online (official)
• Chicago Manual of Style Method (Purdue University OWL) Be sure to check out the sample paper!
• Chicago Style Citation Guide (Long Island University)

Chicago Style Guide Book

Adapted from:  Information Literacy Concepts: An Open Educational Resource .  Attribution-NonCommercial-ShareAlike 4.0 International (CC BYNC-SA 4.0)  Adapted from Mastering Academic Research developed at Florida Institute of Technology. Adapted from Research Foundations from Seminole State College of Florida Library.

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How to write a research proposal?

Devika rani duggappa.

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Address for correspondence: Dr. Devika Rani Duggappa, 314/2/5, Durganjali Nilaya, 1 st H Cross, 7 th Main, Subbanna Garden, Vijayanagar, Bengaluru - 560 040, Karnataka, India. E-mail: [email protected]

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Writing the proposal of a research work in the present era is a challenging task due to the constantly evolving trends in the qualitative research design and the need to incorporate medical advances into the methodology. The proposal is a detailed plan or ‘blueprint’ for the intended study, and once it is completed, the research project should flow smoothly. Even today, many of the proposals at post-graduate evaluation committees and application proposals for funding are substandard. A search was conducted with keywords such as research proposal, writing proposal and qualitative using search engines, namely, PubMed and Google Scholar, and an attempt has been made to provide broad guidelines for writing a scientifically appropriate research proposal.

Key words: Guidelines, proposal, qualitative, research

INTRODUCTION

A clean, well-thought-out proposal forms the backbone for the research itself and hence becomes the most important step in the process of conduct of research.[ 1 ] The objective of preparing a research proposal would be to obtain approvals from various committees including ethics committee [details under ‘Research methodology II’ section [ Table 1 ] in this issue of IJA) and to request for grants. However, there are very few universally accepted guidelines for preparation of a good quality research proposal. A search was performed with keywords such as research proposal, funding, qualitative and writing proposals using search engines, namely, PubMed, Google Scholar and Scopus.

Five ‘C’s while writing a literature review

BASIC REQUIREMENTS OF A RESEARCH PROPOSAL

A proposal needs to show how your work fits into what is already known about the topic and what new paradigm will it add to the literature, while specifying the question that the research will answer, establishing its significance, and the implications of the answer.[ 2 ] The proposal must be capable of convincing the evaluation committee about the credibility, achievability, practicality and reproducibility (repeatability) of the research design.[ 3 ] Four categories of audience with different expectations may be present in the evaluation committees, namely academic colleagues, policy-makers, practitioners and lay audiences who evaluate the research proposal. Tips for preparation of a good research proposal include; ‘be practical, be persuasive, make broader links, aim for crystal clarity and plan before you write’. A researcher must be balanced, with a realistic understanding of what can be achieved. Being persuasive implies that researcher must be able to convince other researchers, research funding agencies, educational institutions and supervisors that the research is worth getting approval. The aim of the researcher should be clearly stated in simple language that describes the research in a way that non-specialists can comprehend, without use of jargons. The proposal must not only demonstrate that it is based on an intelligent understanding of the existing literature but also show that the writer has thought about the time needed to conduct each stage of the research.[ 4 , 5 ]

CONTENTS OF A RESEARCH PROPOSAL

The contents or formats of a research proposal vary depending on the requirements of evaluation committee and are generally provided by the evaluation committee or the institution.

In general, a cover page should contain the (i) title of the proposal, (ii) name and affiliation of the researcher (principal investigator) and co-investigators, (iii) institutional affiliation (degree of the investigator and the name of institution where the study will be performed), details of contact such as phone numbers, E-mail id's and lines for signatures of investigators.

The main contents of the proposal may be presented under the following headings: (i) introduction, (ii) review of literature, (iii) aims and objectives, (iv) research design and methods, (v) ethical considerations, (vi) budget, (vii) appendices and (viii) citations.[ 4 ]

Introduction

It is also sometimes termed as ‘need for study’ or ‘abstract’. Introduction is an initial pitch of an idea; it sets the scene and puts the research in context.[ 6 ] The introduction should be designed to create interest in the reader about the topic and proposal. It should convey to the reader, what you want to do, what necessitates the study and your passion for the topic.[ 7 ] Some questions that can be used to assess the significance of the study are: (i) Who has an interest in the domain of inquiry? (ii) What do we already know about the topic? (iii) What has not been answered adequately in previous research and practice? (iv) How will this research add to knowledge, practice and policy in this area? Some of the evaluation committees, expect the last two questions, elaborated under a separate heading of ‘background and significance’.[ 8 ] Introduction should also contain the hypothesis behind the research design. If hypothesis cannot be constructed, the line of inquiry to be used in the research must be indicated.

Review of literature

It refers to all sources of scientific evidence pertaining to the topic in interest. In the present era of digitalisation and easy accessibility, there is an enormous amount of relevant data available, making it a challenge for the researcher to include all of it in his/her review.[ 9 ] It is crucial to structure this section intelligently so that the reader can grasp the argument related to your study in relation to that of other researchers, while still demonstrating to your readers that your work is original and innovative. It is preferable to summarise each article in a paragraph, highlighting the details pertinent to the topic of interest. The progression of review can move from the more general to the more focused studies, or a historical progression can be used to develop the story, without making it exhaustive.[ 1 ] Literature should include supporting data, disagreements and controversies. Five ‘C's may be kept in mind while writing a literature review[ 10 ] [ Table 1 ].

Aims and objectives

The research purpose (or goal or aim) gives a broad indication of what the researcher wishes to achieve in the research. The hypothesis to be tested can be the aim of the study. The objectives related to parameters or tools used to achieve the aim are generally categorised as primary and secondary objectives.

Research design and method

The objective here is to convince the reader that the overall research design and methods of analysis will correctly address the research problem and to impress upon the reader that the methodology/sources chosen are appropriate for the specific topic. It should be unmistakably tied to the specific aims of your study.

In this section, the methods and sources used to conduct the research must be discussed, including specific references to sites, databases, key texts or authors that will be indispensable to the project. There should be specific mention about the methodological approaches to be undertaken to gather information, about the techniques to be used to analyse it and about the tests of external validity to which researcher is committed.[ 10 , 11 ]

The components of this section include the following:[ 4 ]

Population and sample

Population refers to all the elements (individuals, objects or substances) that meet certain criteria for inclusion in a given universe,[ 12 ] and sample refers to subset of population which meets the inclusion criteria for enrolment into the study. The inclusion and exclusion criteria should be clearly defined. The details pertaining to sample size are discussed in the article “Sample size calculation: Basic priniciples” published in this issue of IJA.

Data collection

The researcher is expected to give a detailed account of the methodology adopted for collection of data, which include the time frame required for the research. The methodology should be tested for its validity and ensure that, in pursuit of achieving the results, the participant's life is not jeopardised. The author should anticipate and acknowledge any potential barrier and pitfall in carrying out the research design and explain plans to address them, thereby avoiding lacunae due to incomplete data collection. If the researcher is planning to acquire data through interviews or questionnaires, copy of the questions used for the same should be attached as an annexure with the proposal.

Rigor (soundness of the research)

This addresses the strength of the research with respect to its neutrality, consistency and applicability. Rigor must be reflected throughout the proposal.

It refers to the robustness of a research method against bias. The author should convey the measures taken to avoid bias, viz. blinding and randomisation, in an elaborate way, thus ensuring that the result obtained from the adopted method is purely as chance and not influenced by other confounding variables.

Consistency

Consistency considers whether the findings will be consistent if the inquiry was replicated with the same participants and in a similar context. This can be achieved by adopting standard and universally accepted methods and scales.

Applicability

Applicability refers to the degree to which the findings can be applied to different contexts and groups.[ 13 ]

Data analysis

This section deals with the reduction and reconstruction of data and its analysis including sample size calculation. The researcher is expected to explain the steps adopted for coding and sorting the data obtained. Various tests to be used to analyse the data for its robustness, significance should be clearly stated. Author should also mention the names of statistician and suitable software which will be used in due course of data analysis and their contribution to data analysis and sample calculation.[ 9 ]

Ethical considerations

Medical research introduces special moral and ethical problems that are not usually encountered by other researchers during data collection, and hence, the researcher should take special care in ensuring that ethical standards are met. Ethical considerations refer to the protection of the participants' rights (right to self-determination, right to privacy, right to autonomy and confidentiality, right to fair treatment and right to protection from discomfort and harm), obtaining informed consent and the institutional review process (ethical approval). The researcher needs to provide adequate information on each of these aspects.

Informed consent needs to be obtained from the participants (details discussed in further chapters), as well as the research site and the relevant authorities.

When the researcher prepares a research budget, he/she should predict and cost all aspects of the research and then add an additional allowance for unpredictable disasters, delays and rising costs. All items in the budget should be justified.

Appendices are documents that support the proposal and application. The appendices will be specific for each proposal but documents that are usually required include informed consent form, supporting documents, questionnaires, measurement tools and patient information of the study in layman's language.

As with any scholarly research paper, you must cite the sources you used in composing your proposal. Although the words ‘references and bibliography’ are different, they are used interchangeably. It refers to all references cited in the research proposal.

Successful, qualitative research proposals should communicate the researcher's knowledge of the field and method and convey the emergent nature of the qualitative design. The proposal should follow a discernible logic from the introduction to presentation of the appendices.

Financial support and sponsorship

Conflicts of interest.

There are no conflicts of interest.

• 1. McGranaghan M. Guidelines on Writing a Research Proposal. [Last accessed on 2016 Jun 25]. Available from: https://www.2.hawaii.edu/~matt/proposal.html .
• 2. Nte AR, Awi DD. Research proposal writing: Breaking the myth. Niger J Med. 2006;15:373–81. doi: 10.4314/njm.v15i4.37249. [ DOI ] [ PubMed ] [ Google Scholar ]
• 3. Saunderlin G. Writing a research proposal: The critical first step for successful clinical research. Gastroenterol Nurs. 1994;17:48–56. [ PubMed ] [ Google Scholar ]
• 4. Klopper H. The qualitative research proposal. Curationis. 2008;31:62–72. doi: 10.4102/curationis.v31i4.1062. [ DOI ] [ PubMed ] [ Google Scholar ]
• 5. Singh MD, Cameron C, Duff D. Writing proposals for research funds. Axone. 2005;26:26–30. [ PubMed ] [ Google Scholar ]
• 6. Burns N, Grove SK. The Practice of Nursing Research: Conduct, Critique and Utilization. 5th ed. St. Louis: Elsevier Saunders; 2005. pp. 667–8. [ Google Scholar ]
• 7. Sandelowski M, Barroso J. Writing the proposal for a qualitative research methodology project. Qual Health Res. 2003;13:781–820. doi: 10.1177/1049732303013006003. [ DOI ] [ PubMed ] [ Google Scholar ]
• 8. Krathwohl DR. How to Prepare a Dissertation Proposal: Suggestions for Students in Education and the Social and Behavioral Sciences. Syracuse, NY: Syracuse University Press; 2005. pp. 45–7. [ Google Scholar ]
• 9. Balakumar P, Inamdar MN, Jagadeesh G. The Critical Steps for Successful Research: The Research Proposal and Scientific Writing: A Report on the Pre-Conference Workshop Held in Conjunction with the 64th Annual Conference of the Indian Pharmaceutical Congress-2012. J Pharmacol Pharmacother. 2013;4:130–18. doi: 10.4103/0976-500X.110895. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]
• 10. Labaree RV. Organizing Your Social Sciences Research Paper: Writing a Research Proposal. [Last accessed on 2016 Jun 25]. Available from: http://www.libguides.usc.edu/writingguide .
• 11. Research Proposal. [Last accessed on 2016 Jul 04]. Available from: http://www.web.stanford.edu/~steener/gendertech/assignments/ResearchProposal.pdf .
• 12. Burns N, Grove SK. The Practice of Nursing Research: Conduct, Critique and Utilization. 5th ed. St. Louis: Elsevier Saunders; 2005. p. 40. [ Google Scholar ]
• 13. Sliep Y, Poggenpoel M, Gmeiner A. A care counselling model for HIV reactive patients in rural Malawi – Part II. Curationis. 2001;24:66–74. doi: 10.4102/curationis.v24i3.855. [ DOI ] [ PubMed ] [ Google Scholar ]
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Citing sources.

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• Avoiding Plagiarism
• Citation Managers (EndNote, Refworks, Mendeley, Zotero)

Tools for Managing Citations

• START HERE: Support for Citation Tools

There are many different tools available to help you to:

• import citations
• store and organize your PDFs
• insert citations into documents
• share your citations and papers with others
• collaborate with others

These products change constantly, so keeping up can be difficult. Try the  Comparison of Reference Management Software  entry in Wikipedia for your general questions. Also, look at the  citation manager comparison chart  at Welch Library to evaluate the features, flexibility, and accessibility of each option.

Librarians only offer very limited help with most of those products. Each tab will tell you where you can get help. 

RefWorks, EndNote, Mendeley, and Zotero each come with their own set of strengths and weaknesses, but these four tools offer the same basic features, such as:

• Export a batch of references from a database and into the tool
• Organize these references in folders 
• Share your citations with collaborators
• Create a bibliography of your citations in a variety of styles
• Add a Microsoft Word or Google Docs (available in RefWorks and Zotero) plug-in that lets you cite while you write your document

RefWorks  is an online citation manager that helps you keep track of citations to books, articles, and other documents. It creates properly formatted bibliographies, and will insert citations into your documents. Organize, read, annotate, and highlight full-text documents individually, or share privately with members of your institution or with any RefWorks user in a collaborative environment. 

• Refworks is free to all JHU users
• It is web-based, so doesn't need to be downloaded
• Unlimited storage and annotation capabilities
• Information for JHU alumni

To get started:  Use the JHU Libraries' guide to using RefWorks:  https://guides.library.jhu.edu/refworks 

Refworks' own guide:   http://proquest.libguides.com/refworks, endnote has both a desktop and a web based version. , the desktop version is called “endnote desktop” or “endnote on the desktop.” the web version is called “endnote online.” endnote desktop is a paid version that can be purchased through the jhu software portal. the online library can contain an unlimited number of references and unlimited attachments (but be aware that the web version is more limited than the regular desktop endnote)..

• You will be asked to register, if you haven't already. Here is  the Quick Start guide .
• Academic departments wanting to purchase EndNote can go to the JHU portal at: my.jhu.edu --> Technology --> My Software --> click the software catalog link, and search for EndNote 

To get started: 

• JHU Welch Medical Library EndNote Guide:  https://browse.welch.jhmi.edu/citation-management/endnote 
• EndNote's customer support page:  https://support.clarivate.com/Endnote/s/?language=en_US

Mendeley  is a free online tool that helps you collect, manage, and cite research sources. It's easy to use and accessible within your web browser and/or on your desktop.

Mendeley allows you to organize, annotate, and highlight PDFs, add to your citations, organize them into collections for different projects, and create bibliographies using Word or OpenOffice. It is available to use in any web browser.  Mendeley also has a downloadable desktop application for your Mendeley library. Note that Mendeley has a  cost  if you want to store and annotate more than 2G of documents. 

Help Guides: 

• Mendeley Help Guides:  https://www.mendeley.com/guides
• GradCoach guide to using Mendeley: https://youtu.be/PJXnfBSq4Lg?feature=shared 

To start using Mendeley, follow these steps:

• Open your favorite web browser and go to   www.mendeley.com . Click "Create Account" to make an Elsevier account. It's important to note that  you should NOT click "Sign in via your institution " . Simply use your preferred email address to make an account. 
• From the Mendeley homepage , download the Mendeley Reference Manager for Desktop by clicking on the "download" button in the top right-hand corner. 
• Then install the  Mendeley Web Importer  for Chrome, Firefox, or Safari. This allows you to save references to your Mendeley library with one click.
• You can also integrate Mendeley with Microsoft Word by downloading the  Mendeley Cite  plugin. 

Zotero  is a free tool that collects, manages, and cites research sources. It's easy to use and lives in your web browser where you do your work.

Zotero can be downloaded as a standalone version that works with the Chrome, Safari, Firefox, or Edge browsers. Note that Zotero has a cost if you want to store and annotate more than 400 MB of documents. 

• Zotero Help and Support:  http://www.zotero.org/support/
• Oregon State University Library Zotero Guide:  http://guides.library.oregonstate.edu/zotero
• GradCoach YouTube guide to using Zotero:  http://youtu.be/tnbwKj6-pD8?feature=shared  
• A quick YouTube Introduction to Zotero: http://youtu.be/Iq7V2X5x2Pk?si=Q-NgFzgXalSfkjYu

To get started with Zotero:

Open your favorite web browser and go to   https://www.zotero.org/user/login/ . Click "Register for a Free Account," using your preferred email address.

From the Zotero homepage , download the Zotero Reference Manager for Desktop by clicking on the "download" button in the top right  corner. 

Then install the  Zotero Connector  for Chrome, Firefox, Edge, or Safari. This allows you to save references to your Zotero library with one click.

You can also integrate Zotero with Microsoft Word, Google Docs or LibreOffice Plugins . 

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Purdue Online Writing Lab Purdue OWL® College of Liberal Arts

MLA In-Text Citations: The Basics

Welcome to the Purdue OWL

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Copyright ©1995-2018 by The Writing Lab & The OWL at Purdue and Purdue University. All rights reserved. This material may not be published, reproduced, broadcast, rewritten, or redistributed without permission. Use of this site constitutes acceptance of our terms and conditions of fair use.

Guidelines for referring to the works of others in your text using MLA style are covered throughout the  MLA Handbook  and in chapter 7 of the  MLA Style Manual . Both books provide extensive examples, so it's a good idea to consult them if you want to become even more familiar with MLA guidelines or if you have a particular reference question.

Basic in-text citation rules

In MLA Style, referring to the works of others in your text is done using parenthetical citations . This method involves providing relevant source information in parentheses whenever a sentence uses a quotation or paraphrase. Usually, the simplest way to do this is to put all of the source information in parentheses at the end of the sentence (i.e., just before the period). However, as the examples below will illustrate, there are situations where it makes sense to put the parenthetical elsewhere in the sentence, or even to leave information out.

General Guidelines

• The source information required in a parenthetical citation depends (1) upon the source medium (e.g. print, web, DVD) and (2) upon the source’s entry on the Works Cited page.
• Any source information that you provide in-text must correspond to the source information on the Works Cited page. More specifically, whatever signal word or phrase you provide to your readers in the text must be the first thing that appears on the left-hand margin of the corresponding entry on the Works Cited page.

In-text citations: Author-page style

MLA format follows the author-page method of in-text citation. This means that the author's last name and the page number(s) from which the quotation or paraphrase is taken must appear in the text, and a complete reference should appear on your Works Cited page. The author's name may appear either in the sentence itself or in parentheses following the quotation or paraphrase, but the page number(s) should always appear in the parentheses, not in the text of your sentence. For example:

Both citations in the examples above, (263) and (Wordsworth 263), tell readers that the information in the sentence can be located on page 263 of a work by an author named Wordsworth. If readers want more information about this source, they can turn to the Works Cited page, where, under the name of Wordsworth, they would find the following information:

Wordsworth, William. Lyrical Ballads . Oxford UP, 1967.

In-text citations for print sources with known author

For print sources like books, magazines, scholarly journal articles, and newspapers, provide a signal word or phrase (usually the author’s last name) and a page number. If you provide the signal word/phrase in the sentence, you do not need to include it in the parenthetical citation.

These examples must correspond to an entry that begins with Burke, which will be the first thing that appears on the left-hand margin of an entry on the Works Cited page:

Burke, Kenneth. Language as Symbolic Action: Essays on Life, Literature, and Method . University of California Press, 1966.

In-text citations for print sources by a corporate author

When a source has a corporate author, it is acceptable to use the name of the corporation followed by the page number for the in-text citation. You should also use abbreviations (e.g., nat'l for national) where appropriate, so as to avoid interrupting the flow of reading with overly long parenthetical citations.

In-text citations for sources with non-standard labeling systems

If a source uses a labeling or numbering system other than page numbers, such as a script or poetry, precede the citation with said label. When citing a poem, for instance, the parenthetical would begin with the word “line”, and then the line number or range. For example, the examination of William Blake’s poem “The Tyger” would be cited as such:

The speaker makes an ardent call for the exploration of the connection between the violence of nature and the divinity of creation. “In what distant deeps or skies. / Burnt the fire of thine eyes," they ask in reference to the tiger as they attempt to reconcile their intimidation with their relationship to creationism (lines 5-6).

Longer labels, such as chapters (ch.) and scenes (sc.), should be abbreviated.

In-text citations for print sources with no known author

When a source has no known author, use a shortened title of the work instead of an author name, following these guidelines.

Place the title in quotation marks if it's a short work (such as an article) or italicize it if it's a longer work (e.g. plays, books, television shows, entire Web sites) and provide a page number if it is available.

Titles longer than a standard noun phrase should be shortened into a noun phrase by excluding articles. For example, To the Lighthouse would be shortened to Lighthouse .

If the title cannot be easily shortened into a noun phrase, the title should be cut after the first clause, phrase, or punctuation:

In this example, since the reader does not know the author of the article, an abbreviated title appears in the parenthetical citation, and the full title of the article appears first at the left-hand margin of its respective entry on the Works Cited page. Thus, the writer includes the title in quotation marks as the signal phrase in the parenthetical citation in order to lead the reader directly to the source on the Works Cited page. The Works Cited entry appears as follows:

"The Impact of Global Warming in North America." Global Warming: Early Signs . 1999. www.climatehotmap.org/. Accessed 23 Mar. 2009.

If the title of the work begins with a quotation mark, such as a title that refers to another work, that quote or quoted title can be used as the shortened title. The single quotation marks must be included in the parenthetical, rather than the double quotation.

Parenthetical citations and Works Cited pages, used in conjunction, allow readers to know which sources you consulted in writing your essay, so that they can either verify your interpretation of the sources or use them in their own scholarly work.

Author-page citation for classic and literary works with multiple editions

Page numbers are always required, but additional citation information can help literary scholars, who may have a different edition of a classic work, like Marx and Engels's  The Communist Manifesto . In such cases, give the page number of your edition (making sure the edition is listed in your Works Cited page, of course) followed by a semicolon, and then the appropriate abbreviations for volume (vol.), book (bk.), part (pt.), chapter (ch.), section (sec.), or paragraph (par.). For example:

Author-page citation for works in an anthology, periodical, or collection

When you cite a work that appears inside a larger source (for instance, an article in a periodical or an essay in a collection), cite the author of the  internal source (i.e., the article or essay). For example, to cite Albert Einstein's article "A Brief Outline of the Theory of Relativity," which was published in  Nature  in 1921, you might write something like this:

See also our page on documenting periodicals in the Works Cited .

Citing authors with same last names

Sometimes more information is necessary to identify the source from which a quotation is taken. For instance, if two or more authors have the same last name, provide both authors' first initials (or even the authors' full name if different authors share initials) in your citation. For example:

Citing a work by multiple authors

For a source with two authors, list the authors’ last names in the text or in the parenthetical citation:

Corresponding Works Cited entry:

Best, David, and Sharon Marcus. “Surface Reading: An Introduction.” Representations , vol. 108, no. 1, Fall 2009, pp. 1-21. JSTOR , doi:10.1525/rep.2009.108.1.1

For a source with three or more authors, list only the first author’s last name, and replace the additional names with et al.

Franck, Caroline, et al. “Agricultural Subsidies and the American Obesity Epidemic.” American Journal of Preventative Medicine , vol. 45, no. 3, Sept. 2013, pp. 327-333.

Citing multiple works by the same author

If you cite more than one work by an author, include a shortened title for the particular work from which you are quoting to distinguish it from the others. Put short titles of books in italics and short titles of articles in quotation marks.

Citing two articles by the same author :

Citing two books by the same author :

Additionally, if the author's name is not mentioned in the sentence, format your citation with the author's name followed by a comma, followed by a shortened title of the work, and, when appropriate, the page number(s):

Citing multivolume works

If you cite from different volumes of a multivolume work, always include the volume number followed by a colon. Put a space after the colon, then provide the page number(s). (If you only cite from one volume, provide only the page number in parentheses.)

Citing the Bible

In your first parenthetical citation, you want to make clear which Bible you're using (and underline or italicize the title), as each version varies in its translation, followed by book (do not italicize or underline), chapter, and verse. For example:

If future references employ the same edition of the Bible you’re using, list only the book, chapter, and verse in the parenthetical citation:

John of Patmos echoes this passage when describing his vision (Rev. 4.6-8).

Citing indirect sources

Sometimes you may have to use an indirect source. An indirect source is a source cited within another source. For such indirect quotations, use "qtd. in" to indicate the source you actually consulted. For example:

Note that, in most cases, a responsible researcher will attempt to find the original source, rather than citing an indirect source.

Citing transcripts, plays, or screenplays

Sources that take the form of a dialogue involving two or more participants have special guidelines for their quotation and citation. Each line of dialogue should begin with the speaker's name written in all capitals and indented half an inch. A period follows the name (e.g., JAMES.) . After the period, write the dialogue. Each successive line after the first should receive an additional indentation. When another person begins speaking, start a new line with that person's name indented only half an inch. Repeat this pattern each time the speaker changes. You can include stage directions in the quote if they appear in the original source.

Conclude with a parenthetical that explains where to find the excerpt in the source. Usually, the author and title of the source can be given in a signal phrase before quoting the excerpt, so the concluding parenthetical will often just contain location information like page numbers or act/scene indicators.

Here is an example from O'Neill's  The Iceman Cometh.

WILLIE. (Pleadingly) Give me a drink, Rocky. Harry said it was all right. God, I need a drink.

ROCKY. Den grab it. It's right under your nose.

WILLIE. (Avidly) Thanks. (He takes the bottle with both twitching hands and tilts it to his lips and gulps down the whiskey in big swallows.) (1.1)

Citing non-print or sources from the Internet

With more and more scholarly work published on the Internet, you may have to cite sources you found in digital environments. While many sources on the Internet should not be used for scholarly work (reference the OWL's  Evaluating Sources of Information  resource), some Web sources are perfectly acceptable for research. When creating in-text citations for electronic, film, or Internet sources, remember that your citation must reference the source on your Works Cited page.

Sometimes writers are confused with how to craft parenthetical citations for electronic sources because of the absence of page numbers. However, these sorts of entries often do not require a page number in the parenthetical citation. For electronic and Internet sources, follow the following guidelines:

• Include in the text the first item that appears in the Work Cited entry that corresponds to the citation (e.g. author name, article name, website name, film name).
• Do not provide paragraph numbers or page numbers based on your Web browser’s print preview function.
• Unless you must list the Web site name in the signal phrase in order to get the reader to the appropriate entry, do not include URLs in-text. Only provide partial URLs such as when the name of the site includes, for example, a domain name, like  CNN.com  or  Forbes.com,  as opposed to writing out http://www.cnn.com or http://www.forbes.com.

Miscellaneous non-print sources

Two types of non-print sources you may encounter are films and lectures/presentations:

In the two examples above “Herzog” (a film’s director) and “Yates” (a presentor) lead the reader to the first item in each citation’s respective entry on the Works Cited page:

Herzog, Werner, dir. Fitzcarraldo . Perf. Klaus Kinski. Filmverlag der Autoren, 1982.

Yates, Jane. "Invention in Rhetoric and Composition." Gaps Addressed: Future Work in Rhetoric and Composition, CCCC, Palmer House Hilton, 2002. Address.

Electronic sources

Electronic sources may include web pages and online news or magazine articles:

In the first example (an online magazine article), the writer has chosen not to include the author name in-text; however, two entries from the same author appear in the Works Cited. Thus, the writer includes both the author’s last name and the article title in the parenthetical citation in order to lead the reader to the appropriate entry on the Works Cited page (see below).

In the second example (a web page), a parenthetical citation is not necessary because the page does not list an author, and the title of the article, “MLA Formatting and Style Guide,” is used as a signal phrase within the sentence. If the title of the article was not named in the sentence, an abbreviated version would appear in a parenthetical citation at the end of the sentence. Both corresponding Works Cited entries are as follows:

Taylor, Rumsey. "Fitzcarraldo." Slant , 13 Jun. 2003, www.slantmagazine.com/film/review/fitzcarraldo/. Accessed 29 Sep. 2009. 

"MLA Formatting and Style Guide." The Purdue OWL , 2 Aug. 2016, owl.english.purdue.edu/owl/resource/747/01/. Accessed 2 April 2018.

Multiple citations

To cite multiple sources in the same parenthetical reference, separate the citations by a semi-colon:

Time-based media sources

When creating in-text citations for media that has a runtime, such as a movie or podcast, include the range of hours, minutes and seconds you plan to reference. For example: (00:02:15-00:02:35).

When a citation is not needed

Common sense and ethics should determine your need for documenting sources. You do not need to give sources for familiar proverbs, well-known quotations, or common knowledge (For example, it is expected that U.S. citizens know that George Washington was the first President.). Remember that citing sources is a rhetorical task, and, as such, can vary based on your audience. If you’re writing for an expert audience of a scholarly journal, for example, you may need to deal with expectations of what constitutes “common knowledge” that differ from common norms.

Other Sources

The MLA Handbook describes how to cite many different kinds of authors and content creators. However, you may occasionally encounter a source or author category that the handbook does not describe, making the best way to proceed can be unclear.

In these cases, it's typically acceptable to apply the general principles of MLA citation to the new kind of source in a way that's consistent and sensible. A good way to do this is to simply use the standard MLA directions for a type of source that resembles the source you want to cite.

You may also want to investigate whether a third-party organization has provided directions for how to cite this kind of source. For example, Norquest College provides guidelines for citing Indigenous Elders and Knowledge Keepers⁠ —an author category that does not appear in the MLA Handbook . In cases like this, however, it's a good idea to ask your instructor or supervisor whether using third-party citation guidelines might present problems.

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• SUMMARY AND COMMENT | 
• General Medicine
• Ambulatory Medicine

November 5, 2024

Can a GLP-1 Agonist Alleviate Knee Pain Caused by Osteoarthritis?

David S. Weisman, DO, FACP , reviewing Bliddal H et al. N Engl J Med 2024 Oct 31

Compared with placebo, semaglutide provided some knee pain relief in patients with obesity and OA.

Supervised exercise and weight loss through dieting are first-line treatments for patients with knee pain caused by osteoarthritis (OA). To determine whether weight loss with a glucagon-like peptide-1 (GLP-1)–receptor agonist also would alleviate OA pain, researchers conducted an industry-sponsored trial in 400 patients with obesity (mean body-mass index, 40 kg/m 2 ) and radiographically moderate knee OA, * but without diabetes. Patients were randomized to semaglutide (titrated to 2.4 mg weekly) or placebo. Both groups received dietary and exercise counseling.

At 68 weeks, improvement in pain on a standardized 100-point osteoarthritis pain scale was significantly better in the semaglutide group than in the placebo group (mean score decrease, 42 vs. 28 points, from a mean baseline score of 71 points). Additionally, patients in the semaglutide group were significantly more likely than placebo recipients to have a ≥50% relative reduction in their pain scores (65% vs. 35%). Mean decreases in weight were 14% with semaglutide and 3% with placebo. More patients in the semaglutide group discontinued treatment due to gastrointestinal side effects. Both groups used fewer pain medications during the trial.

Semaglutide, and presumably other GLP-1 agonists, expand our medication options for patients with obesity and radiographically moderate OA who have moderate-to-severe pain. When discussing use of GLP-1 agonists with patients who have obesity, I will include this potential benefit if they also have knee OA. Whether semaglutide alleviates knee pain by mechanisms other than weight loss remains unclear.

* Patients with severe radiographic changes (e.g., large osteophytes, marked joint space narrowing, severe sclerosis, definite bone-end deformity) were excluded from this trial.

Bliddal H et al. Once-weekly semaglutide in persons with obesity and knee osteoarthritis. N Engl J Med 2024 Oct 31; 391:1573. ( https://doi.org/10.1056/NEJMoa2403664 )

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Topics Aging/Geriatrics Nutrition/Obesity Arthritis/Rheumatic Disease

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Contributing Editor

NEJM Journal Watch General Medicine

• Disclosures

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